Ruth finishes with Jay just as they are looking forward to having a baby, Linda comes face to face with an old adversary who threatens her job and the ED catches fire.
As fire ravages the ED, the team pulls together and surprising truths are revealed. Zoe, Dylan, Ruth and Jay are trapped in the hospital - will they make it out alive?
The doors open at the brand new emergency department, but are the team ready to respond when an explosion rocks Holby?
In the aftermath of the Silverton explosion, Sam tries to reconcile a dying Marston with his ex-wife and Tom finds himself investigating a mystery on his first day in the ED.
Linda's sister, Denise, is on the run from social services; she arrives at Holby ED with her teenage daughter, Britney, and young son, Joe, and turns her sibling's life upside down.